Research into brain tumours in children and teenagers
Current Projects
*NEW* University of Cambridge (Professor V Peter Collins) (2010 – 2013), Molecular-genetic and epigenetic analysis of pilocytic & pilomyxoid astrocytomas and ependymomas
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University of Cambridge (Dr Howard Ring) (2008 – 2010), Rates of psychiatric illness in long-term survivors of early childhood brain tumours
*NEW* Institute of Cancer Research, Royal Marsden NHS Foundation Trust (Dr Louis Chesler) (2010 – 2013), Systematic analysis of the role of MYCN in the formation and progression of high-grade, anaplastic medulloblastoma
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University of Leeds (Professor Patricia McKinney) (2007 – 2010), UK Case control study of possible causes of brain tumours in children, teenagers and young adults: a pilot study
University of Nottingham (Dr Richard Grundy) (2008 – 2011), Genome-wide molecular characterisation of supratentorial PNET (sPNET) – II
University of Newcastle (Dr Steven Clifford) (2007 – 2010), The molecular basis of childhood medulloblastoma: from genomics to improved therapies
University of Newcastle (Dr Steven Clifford) (2008 – 2010), A feasibility study of real-time biological characterisation of medulloblastoma
*NEW* University of Newcastle (Dr Steven Clifford) (2010 – 2013), Biomarker discovery for improved disease risk assessment and therapy of childhood medulloblastoma
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University of Southampton (Dr Colin Kennedy) (2007 – 2010), An in depth study over time on the effect of child and parent factors on perceived quality of life of children treated for brain tumour
*NEW* Royal Victoria Infirmary, Newcastle (Dr Simon Bailey) (2010) - A phase II multi-centre study of the concomitant and prolonged adjuvant temozolomide with radiotherapy in diffuse pontine gliomas - Jointly funded with Cancer Research UK
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Research into high-grade tumours
Current Projects
*NEW* University of Cambridge (Dr Colin Watts) (2010), An Evaluation of the tolerability and feasibility of combining 5-Amino-Levulinic Acid (5-ALA) with Carmustine Wafers (Gliadel®) in the surgical management of primary glioblastoma – Jointly funded with Cancer Research UK
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University of Wolverhampton (Dr Weiguang Wang) (2008 – 2011), Targeting the Nuclear Factor kappaB (NF-kB) pathway to improve chemotherapy of glioblastoma multiforme
Institute of Neurology, London (Professor Sebastian Brandner) (2008 – 2011), Analysis of LOH 1p/19q and MGMT methylation in patients with malignant gliomas
Institute of Cancer Research, Royal Marsden NHS Foundation Trust (Dr Nada Al-Saffar) (2009 – 2012), Establishing non-invasive biomarkers of the efficacy of novel phophoinositide 3-kinase inhibitors in paediatric high-grade glioma by magnetic resonance spectroscopy
Research into low-grade tumours
Current Projects
Queen Mary, University of London (Professor Denise Sheer) (2007 – 2010), Molecular genetic and epigenetic analysis of paediatric low-grade gliomas
University of Nottingham (Professor Richard Grundy) (2007 – 2010), Advanced magnetic resonance imaging and metabolic studies of low-grade gliomas of childhood
University of Nottingham (Dr Paul Scotting) (2006 – 2010), Reassessing the origins of cranial germ cell tumours
Research across brain tumour types and age group
Current Projects
*NEW* University College London (Dr Susan Short) (2010), Clinical Trials Project Officer – Jointly funded with Cancer Research UK
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University of Bristol/Sheffield (Dr Ingram Wright) (2008 – 2010), Development and evaluation of a neuropsychological follow-up service for survivors of childhood brain tumours
*NEW* University of Newcastle (Professor Steven Clifford) (2010), Central support for CCLG CNS Tumour clinical trials pathology review and biological studies: funding of a Biomedical Scientist – Jointly funded with Cancer Research UK
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Clinical and Research Training
Current Projects
University of Edinburgh (Dr Robin Grant) (2009-2012), Clinical fellowship in neurological neuro-oncology
Research Centres of Excellence
In 2008, we launched our first dedicated research centre of excellence at University College London at a cost of £1,667,511 over five years. The Samantha Dickson Brain Cancer Unit is housed in the UCL Cancer Institute, and has been supported by Brian Cross Memorial Trust. The research is being led by Dr Paolo Salomoni and Dr Steve Pollard, both talented researchers with considerable experience in brain tumour research.
