Research into brain tumours in children and teenagers
Total research costs for current projects £973,859
Current projects
University of Cambridge (Professor V. Peter Collins) (2006 – 2009), Genome-wide analysis of ependymomas and pilocytic astrocytomas
University of Cambridge (Dr Howard Ring) (2008 – 2009), Rates of psychiatric illness in long-term survivors of early childhood brain tumours
University of Liverpool (Dr Violaine Sée) (2006 – 2009), Imaging of molecular dynamics and cell fate to identify new targets for medulloblastoma therapy
University of Leeds (Professor Patricia McKinney) (2007 – 2009), UK Case control study of possible causes of brain tumours in children, teenagers and young adults: A pilot study
Institute of Neurology, London (Dr Tracy Warr) (2008 – 2009), Epigenetic silencing of gene expression in paediatric intracranial ependymoma
University of Nottingham (Dr Richard Grundy) (2008 – 2011), Genome-wide molecular characterisation of supratentorial PNET (sPNET) – II
University of Newcastle (Dr Steven Clifford) (2007 – 2010), The molecular basis of childhood medulloblastoma: from genomics to improved therapies
University of Newcastle (Dr Steven Clifford) (2008 – 2009), A feasibility study of real-time biological characterisation of medulloblastoma
University of Nottingham (Dr Beth Coyle) (2007 – 2009), The contribution of drug-resistant cancer stem cells to paediatric brain tumours
University of Southampton (Dr Colin Kennedy) (2007 – 2009), An extension to: “An in depth study over time on the effect of child and parent factors on perceived quality of life of children treated for brain tumour”
Research into high grade tumours
Total research costs for current projects £695, 769
Current projects
University of Cambridge (Professor Peter Collins) (2006 – 2009), Detailed analysis of two genetically altered regions of the genome in astrocytic gliomas by means of chromosomal tile path array-CGH
University of Wolverhampton (Professor John Darling) (2008 – 2011), Targeting the Nuclear Factor kappaB (NF-kB) pathway to improve chemotherapy of glioblastoma multiforme
Institute of Neurology, London (Professor Sebastian Brandner) (2008 – 2011), Analysis of LOH 1p/19q and MGMT methylation in patients with malignant gliomas
Royal Marsden NHS Trust (Professor Andy Pearson) (2009 – 2012), Establishing non-invasive biomarkers of the efficacy of novel phophoinositide 3-kinase inhibitors in paediatric high-grade glioma by magnetic resonance spectroscopy
University of Nottingham (Professor Richard Grundy) (2007 – 2009), Comprehensive mapping of gene expression and genomic gains and losses in paediatric high grade gliomas and the contribution of drug resistant cancer stem cells in paediatric brain tumours
Research into low grade tumours
Total research costs for current projects £432,525
Current projects
Queen Mary, University of London (Professor Denise Sheer) (2007 – 2010), Molecular genetic and epigenetic analysis of paediatric low grade gliomas
Institute of Neurology, London (Dr Tracy Warr) (2007 – 2009), Radiological and molecular markers of subsequent behaviour in adult low-grade glioma
University of Nottingham (Professor Richard Grundy) (2007 – 2010), Advanced magnetic resonance imaging and metabolic studies of low grade gliomas of childhood
Research across brain tumour types and age group
Total research costs for current projects £387,337
Current projects
University of Bristol/Sheffield (Dr Ingram Wright) (2008 – 2010), Development and evaluation of a neuropsychological follow-up service for survivors of childhood brain tumours
University of Cambridge (Dr Koichi Ichimura) (2006 – 2009), A genome wide methylation analysis of oligodendroglial tumours
University of Nottingham (Dr Paul Scotting) (2006 – 2009), Reassessing the origins of cranial germ cell tumours
Institute of Neurology, London (Professor Sebastian Brandner) (2006 – 2008), Wnt signalling in neural stem cell differentiation and tumourigenesis of the central nervous system: Initial study
Research Centres of Excellence
In 200
8, we launched our first dedicated research centre of excellence at University College London at a cost of £1,667,511 over five years. We hope that this will be the first of a number of such centres over the coming years.